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In this issue:
Viral Glycoprotein Assortment to Distinct Lipid Microdomains and Virions
Negative Regulation of Innate Immune Signaling in Drosophila
Microbial Activation of Natural Killer T Cells Triggers Liver Autoimmunity
Mycobacterium tuberculosis Phosphatase Inhibits Phagolysosome Fusion
Mycobacterium tuberculosis Senses Host-Generated Carbon Monoxide
Featured Article
The Featured Article is freely available to all readers. HIV-1 Assembly: Viral Glycoproteins Segregate Quantally to Lipid Rafts that Associate Individually with HIV-1 Capsids and Virions |
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After synthesis, HIV-1 structural protein Gag traffics to the late endosome/plasma membrane, associates with HIV Env glycoprotein, and forms infectious virions. While Env and Gag are known migrate to lipid microdomains, their stoichiometry and specificity of interaction are less clear. Leung et al. analyze the association of HIV Env and Ebola glycoprotein GP with Gag coexpressed in the same cell. Both viral glycoproteins were expressed, but each associated independently with Gag, giving rise to distinct virion populations, each with a single glycoprotein type. Thus, a single Gag particle associates “quantally” with one lipid microdomain, containing homogeneous viral envelope proteins, to assemble functional virions. |
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New Cell Press Podcast
In our new podcast, we hear about a paper in the latest issue of Cell Host & Microbe and learn how an insidious bacterial pathogen, Mycobacterium tuberculosis, subverts the host immune response. We also hear about a study in the April 18th issue of Cell by Rudolph Jaenisch, in which mature B cells are reprogrammed to a pluripotent state, as well as the loss of two key tumor suppressor proteins in glioblastoma brain tumors reported in this month's issue of Cancer Cell. Finally, stay tuned for our quarterly roundup of exciting research highlights published in the Cell Press family of journals.
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Host-Microbe
Papers in Other Cell Press Journals
Immunity, online ahead of print,
10.1016/j.immuni.2008.02.020
Human
Effector and Memory CD8+ T Cell Responses to Smallpox and Yellow Fever
Vaccines
Joseph D. Miller, Robbert G. van der Most, Rama S. Akondy, John T.
Glidewell, Sophia Albott, David Masopust, Kaja Murali-Krishna, Patryce
L. Mahar, Srilatha Edupuganti, Susan Lalor, Stephanie Germon, Carlos
Del Rio, Mark J. Mulligan, Silvija I. Staprans, John D. Altman, Mark B.
Feinberg, and Rafi Ahmed
Trends in
Pharmacological Sciences, Volume 29, Issue 5, May 2008, pp. 241–249
*FREE
REVIEW*
Drugging
the Plasmodium kinome: the benefits of
academia–industry synergy
Didier Leroy and Christian Doerig
Trends
in Molecular Medicine, Volume 14, Issue 5, May 2008, pp.
191–198 *FREE
REVIEW*
The
immune privilege of the oral mucosa
Natalija Novak, Jörg Haberstok, Thomas Bieber, and Jean-Pierre
Allam
Movie Gallery
The movies are freely available to all readers. Explore the complete Movie Gallery.
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Host
Cell Traversal Is Important for Progression of the Malaria Parasite
through the Dermis to the Liver Malaria parasite (pseudocolored red, green, or blue as a function of depth) gliding on liver cells. Time-lapse microscopy for 33 minutes. |
Top 20 Articles
These are the Top 20 Papers by download from the Cell Host & Microbe web site for the last 30 days.
Announcements
Cell Host & Microbe would like to congratulate editorial board members Jules A. Hoffmann and Michael Oldstone for their induction into the National Academy of Sciences.
Cell Press announces new partnership with the
Biophysical Society
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Featured Job
Senior Scientists and Scientists Genentech, Inc. is currently seeking Senior Scientists and Scientists in our Department of Microbial Pathogenesis in our South San Francisco headquarters. All positions require a PhD, MD or PhD/MD. For 30 years, Genentech has been at the forefront of the biotechnology industry, using human genetic information to develop novel medicines for serious and life-threatening diseases. Today, Genentech is among the world’s leading biotech companies, with multiple therapies on the market. For more information, click here. |
